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Cancer Genomics and Genetics Lab

Manjusha Dixit's Lab

FRG1 is a direct transcriptional regulator of nonsense-mediated mRNA decay genes

DOI: 10.1016/j.ygeno.2022.110539

Ananya Palo
PhD, SBS NISER

Manjusha Dixit
Associate Professor
SBS NISER

Research Highlights

Elucidating the role of FRG1 in cancer progression

Our lab is currently working with multiple cancer types such as breast, gastric, liver, and neuronal cancer to unravel the role and molecular mechanism of FRG1 functioning.

Unraveling the role of FRG1 in Nonsense-mediated mRNA decay

Mechanistically studies suggest FRG1's role in RNA biogenesis which may have implications in multiple physiological processes and diseases, including tumorigenesis. Its probable role as hnRNP and association with NMD-related genes prompted us to look into FRG1's effect on NMD gene expression and the mechanism. Using microarray profiling in cell lines, we found that FRG1 altered the mRNA surveillance pathway and associated pathways, such as RNA transport and spliceosome machinery molecules.

Demography and molecular mechanism of genes in gall bladder cancer

Gall blader cancer is prevlent in eastern indian. There are different MPPs and CYP family member involved. We are currently focusing on those genes and trying to unravel the molecular machinsm under it

EEF1A2 association with ER receptor in breast cancer

EEF1A2 was associated with ER receptor positivity in breast cancer and was involved in its transcriptional regulation. It induced a robust metastatic program in MDA-MB-231 (a triple-negative cell line), and induced significant changes in its invasive and migratory properties via activation of the ERK pathway. This was not the case in MCF7 which is an ER-positive cell line.

Involvement of different IQGAP family domains in breast cancer

IQGAP2, a member of the IQGAP family, functions as a tumor suppressor in most of the cancers. Unlike IQGAP1 and IQGAP3, which function as oncogenes in breast cancer, the role of IQGAP2 is studied extensively by us in cancer.

Tubule networks in HUVECs in response to culture medium of IQGAP2 overexpression MCF7

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