Our lab's broad research interest is to understand the genetics and molecular biology of various human genetic diseases, especially cancer. The lab is currently working on two different aspects of cancer. One group is interested towards the validation and elucidation of the molecular mechanism of putative angiogenic regulators while the other group is trying to understand the molecular mechanism of Gallbladder cancer.
Angiogenesis is a process of formation of blood vessels from pre-existing ones. Angiogenesis is significant for embryo development, wound healing, inflammation, process of reproduction Imbalanced Angiogenesis is also associated causative link with various disorders such as diabetic retinopathy, rheumatoid arthritis, cancer, age related macular degeneration, psoriasis, coronary artery disorder, myocardial infarction, chronic wounds etc. Studies in angiogenesis have shown involvement of wide range of regulators and signalling molecules making it a highly orchestrated process. Thus angiogenesis involves various molecular signals and interaction between among various cell types. These signals and molecules are major therapeutic targets against angiogenesis for treatment of various disorder. Thus aim of our research is identification of novel angiogenic regulators, mechanism of angiogenesis regulation and its therapeutic significance.
Gall-bladder carcinoma (GBC) which is the most common biliary tract cancer, has very poor prognosis and late diagnosis makes it lethal. High risk zone of GBC is in a wide band of north eastern India. These are the states of Uttar Pradesh, Bihar, Odisha, West Bengal and Assam which are known as the GBC belt. As incidence of Gallbladder carcinoma depends highly on geographical location and show ethnic variation, it is possible that some population specific risk factors might be key players for the GBC. Identification of GBC associated genes and elucidation of molecular mechanism can help in establishing molecular (bio) markers and in turn individuals at high risk for the GBC.